Prof. Subhendu Ghosh: Synaptic Plasticity

Professor Subhendu Ghosh is a trailblazing biophysicist 🧬 with a rich academic journey. He earned his Ph.D. in Biophysics, specializing in Ligand-DNA interactions, from Jawaharlal Nehru University in 1984. Prior to that, he obtained an M.Phil. in Biophysics in 1980 and an M.Sc. in Physics in 1978, both from Jawaharlal Nehru University. His academic journey commenced with a B.Sc. from Calcutta University (Presidency College) in 1975. Prof. Ghosh’s educational background reflects his commitment to unraveling the intricacies of biophysical phenomena, establishing him as a notable figure in the field. 👨‍🔬✨

🏥 Experience:

👨‍🔬 Professor Subhendu Ghosh, a seasoned biophysicist, boasts a diverse research portfolio. His expertise encompasses the intricate interactions of DNA with various entities, including carcinogens, anticancer agents, and proteins, focusing on structural nuances. Proficient in spectroscopic methods like absorption, fluorescence, CD & ORD, and well-versed in NMR, he unravels the mysteries of molecular structures. Additionally, his work extends to membrane channels, such as porins and Voltage Dependent Anion Channels, employing biochemical, electrophysiological (patch-clamp), and spectroscopic techniques.

A stalwart in mathematical modeling, he navigates stochastic and nonlinear realms, exploring Fractal Geometry’s applications in biology and computers. His illustrious career spans appointments as a Professor and Head at the University of Delhi South Campus, a Guest Scientist at the Max Planck Institute in Germany, and various roles at esteemed institutions. 🌐 With a relentless passion for unraveling biological complexities, Prof. Ghosh leaves an indelible mark on the world of biophysics.

🔬Research Interest:

🧠 Professor Subhendu Ghosh, a trailblazer in biophysics, delves into the realms of cognitive neuroscience, unraveling the mysteries of human learning and memory. Focused on the neural mechanisms and synaptic dynamics underlying learning, his interdisciplinary approach incorporates Behavioral Science, Neurophysiology, Computer Science (Artificial Neural Network), and Mathematics to decipher the biology of emotions.

⚡ In the realm of ion channels and electrophysiology, Prof. Ghosh pioneers advanced techniques like Patch-Clamp and Bilayer Electrophysiology. His investigations on Voltage Dependent Anion Channels (VDAC) and Gap Junctions in Rat Brain Cells shed light on ion flux control, channel gating, and self-organization, especially post-phosphorylation and ligand interactions.

💔 Delving into apoptosis and neuronal disorders, he explores the intricacies of cell death mediated by Cytochrome C, offering insights into conditions like Alzheimer’s, Parkinson’s, Amnesia, and Dementia through bilayer electrophysiology and patch-clamp studies.

🔍 In theoretical biology, Prof. Ghosh’s expertise shines as he develops mathematical models using Stochastic and Nonlinear Dynamics, employing Fourier Analyses, Fractal Analysis, Noise Analysis, and Computational Analyses to unravel the complexities of biological phenomena. 🌐🔬

🔬Publications:

• Natalizumab for active Crohn’s disease
  • Authors: S Ghosh, E Goldin, FH Gordon, HA Malchow, J Rask-Madsen, …
  • Journal: New England Journal of Medicine
  • Year: 2003
  • Citations: 978
• Influence of intracerebral hemorrhage location on incidence, characteristics, and outcome: population-based study
  • Authors: N Samarasekera, A Fonville, C Lerpiniere, AJ Farrall, JM Wardlaw, …
  • Journal: Stroke
  • Year: 2015
  • Citations: 143
• Bax increases the pore size of rat brain mitochondrial voltage-dependent anion channel in the presence of tBid
  • Authors: J Banerjee, S Ghosh
  • Journal: Biochemical and biophysical research communications
  • Year: 2004
  • Citations: 97
• Mitochondrial VDAC can be phosphorylated by cyclic AMP-dependent protein kinase
  • Authors: AK Bera, S Ghosh, S Das
  • Journal: Biochemical and biophysical research communications
  • Year: 1995
  • Citations: 94
• Dual mode of gating of voltage-dependent anion channel as revealed by phosphorylation
  • Authors: AK Bera, S Ghosh
  • Journal: Journal of Structural Biology
  • Year: 2001
  • Citations: 62
• Wetland macrophytes as toxic metal accumulators
  • Author: S Ghosh
  • Journal: International Journal of Environmental Sciences
  • Year: 2010
  • Citations: 58
• Representation and computational structure-property relations of random media.
  • Authors: D McDowell, S Ghosh, S Kalidindi
  • Journal: JOM: The Journal of The Minerals, Metals & Materials Society (TMS)
  • Year: 2011
  • Citations: 57
• Goiter prevalence and iodine nutritional status of school children in a sub-Himalayan Tarai region of eastern Uttar Pradesh
  • Authors: AK Chandra, A Bhattacharjee, T Malik, S Ghosh
  • Journal: Indian Pediatrics
  • Year: 2008
  • Citations: 56
• The effect of amantadine on an ion channel protein from Chikungunya virus
  • Authors: D Dey, SI Siddiqui, P Mamidi, S Ghosh, CS Kumar, S Chattopadhyay, …
  • Journal: PLoS neglected tropical diseases
  • Year: 2019
  • Citations: 49
• Phosphorylation of rat brain mitochondrial voltage‐dependent anion as a potential tool to control leakage of cytochrome c
  • Authors: J Banerjee, S Ghosh
  • Journal: Journal of neurochemistry
  • Year: 2006
  • Citations: 44

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